Article
Photolabelling of mutant forms of the S1 subunit of pertussis toxin with NAD+.
The Biochemical journal - 15 Jun 1990
Cieplak W, Locht C, Mar V L, Burnette W N, Keith J M
Abstract excerpt
The S1 subunit of pertussis toxin catalyses the hydrolysis of NAD+ (NAD+ glycohydrolysis) and the NAD(+)-dependent ADP-ribosylation of guanine-nucleotide-binding proteins. Recently, the S1 subunit of pertussis toxin was shown to be photolabelled by using radiolabelled NAD+ and u.v.; the primary labelled residue was Glu-129, thereby implicating this residue in the binding of NAD+. Studies from various laboratories...
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