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Article

Apolipoprotein L1 (APOL1) Coding Variants Are Associated With Creatinine Rise After Cardiac Surgery.

Journal of cardiothoracic and vascular anesthesia - 1 Dec 2020

Privratsky Jamie R, Li Yi-Ju, Haynes Carol, Podgoreanu Mihai, Mathew Joseph, Shah Svati H, Stafford-Smith Mark

Abstract excerpt

OBJECTIVE: Acute kidney injury (AKI) is a complication of cardiac surgery that is considerably more common in African Americans (1.5-fold). Although homozygous status for apolipoprotein L1 (APOL1) risk alleles is associated with chronic kidney disease in individuals of African ancestry, whether these coding variants confer AKI risk is unknown. The present study examined whether APOL1 homozygous risk allele status...

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Identifiers

PMID: 32434723
DOI: 10.1053/j.jvca.2020.04.017
PMCID: PMC7655610

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