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Article

The tRNA-modifying function of MnmE is controlled by post-hydrolysis steps of its GTPase cycle.

Nucleic acids research - 1 Jul 2013

Prado Silvia, Villarroya Magda, Medina Milagros, Armengod M-Eugenia

Abstract excerpt

MnmE is a homodimeric multi-domain GTPase involved in tRNA modification. This protein differs from Ras-like GTPases in its low affinity for guanine nucleotides and mechanism of activation, which occurs by a cis, nucleotide- and potassium-dependent dimerization of its G-domains. Moreover, MnmE requires GTP hydrolysis to be functionally active. However, how GTP hydrolysis drives tRNA modification and how the MnmE...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23630314
DOI: 10.1093/nar/gkt320
PMCID: PMC3695501

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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