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Article

Dimerisation-dependent GTPase reaction of MnmE: how potassium acts as GTPase-activating element.

The EMBO journal - 21 Jun 2006

Scrima Andrea, Wittinghofer Alfred

Abstract excerpt

MnmE, a Guanine nucleotide-binding protein conserved between bacteria and man, is involved in the modification of tRNAs. Here we provide biochemical and X-ray structural evidence for a new GTP-hydrolysis mechanism, where the G-domains of MnmE dimerise in a potassium-dependent manner and induce GT...

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Identifiers

PMID: 16763562
DOI: 10.1038/sj.emboj.7601171
PMCID: PMC1500855

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16763562-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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