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Article

Unique structural and nucleotide exchange features of the Rho1 GTPase of Entamoeba histolytica.

The Journal of biological chemistry - 11 Nov 2011

Bosch Dustin E, Wittchen Erika S, Qiu Connie, Burridge Keith, Siderovski David P

Abstract excerpt

The single-celled human parasite Entamoeba histolytica possesses a dynamic actin cytoskeleton vital for its intestinal and systemic pathogenicity. The E. histolytica genome encodes several Rho family GTPases known to regulate cytoskeletal dynamics. EhRho1, the first family member identified, was reported to be insensitive to the Rho GTPase-specific Clostridium botulinum C3 exoenzyme, raising the possibility that...

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PMID: 21930699
DOI: 10.1074/jbc.M111.253898
PMCID: PMC3234748

Genes

C3

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