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Article

Increase in cerebrospinal fluid F2-isoprostanes is related to cognitive decline in APOE ε4 carriers.

Journal of Alzheimer's disease : JAD - 1 Jan 2013

Duits Flora H, Kester Maartje I, Scheffer Peter G, Blankenstein Marinus A, Scheltens Philip, Teunissen Charlotte E, van der Flier Wiesje M

Abstract excerpt

In this longitudinal study we investigated the effect of apolipoprotein E (APOE) genotype on the relation between cognitive decline and cerebrospinal fluid (CSF) F2-isoprostanes, the reference marker for oxidative stress. Twenty non-demented subjects, 58 mild cognitive impairment (MCI) patients, and 63 Alzheimer's disease (AD) patients with measurements of CSF F2-isoprostanes at two time points (with a mean...

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Source

Identifiers

PMID: 23629585
DOI: 10.3233/JAD-122227

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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