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Article

Increased F 2 ‐isoprostanes in Alzheimer's disease: evidence for enhanced lipid peroxidation in vivo

1 Dec 1998

Abstract excerpt

ABSTRACT Alzheimer's disease (AD) includes a group of dementing neurodegenerative disorders that have diverse etiologies but the same hallmark brain lesions. Since oxidative stress may play a role in the pathogenesis of AD and isoprostanes are chemically stable peroxidation products of arachidonic acid, we measured both iPF 2α ‐III and iPF 2α ‐VI using gas chromatography‐mass spectrometry in AD and control...

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PMID: 9837868
DOI: 10.1096/fasebj.12.15.1777

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