Article
The role of GlcNAc-PI-de-N-acetylase gene by gene knockout through homologous recombination and its consequences on survival, growth and infectivity of Leishmania major in in vitro and in vivo conditions.
Acta tropica - 1 Feb 2016
Almani Pooya Ghasemi Nejad, Sharifi Iraj, Kazemi Bahram, Babaei Zahra, Bandehpour Mojgan, Salari Samira, Dezaki Ebrahim Saedi, Tohidi Farideh, Mohammadi Mohammad Ali
Abstract excerpt
At present, there are no efficacious vaccines or effective drugs against leishmaniasis; therefore new and innovative control methods are urgently required. One way to achieve this important goal is through using reverse genetic engineering to evaluate important enzymes, proteins and macromolecules. One of the most important enzymes for Glycosylphosphatidylinositol (GPI) biosynthetic pathways is...
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