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Article

Colorectal cancer in a monoallelic MYH mutation carrier.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract - 1 Aug 2013

Khalaf Racha, Jones Christopher, Strutt Warren, Williamson Paul

Abstract excerpt

Although the literature describes mutY homolog gene (MYH) polyposis as an autosomal recessive syndrome, we report a case of colorectal cancer in a carrier of MYH polyposis. Biallelic mutations in the MYH gene have been shown to increase the risk of colorectal cancer over the lifetime of the mutation carrier.1,2 However, there is no clear consensus in the literature as whether a monoallelic mutation increases the...

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Identifiers

PMID: 23625202
DOI: 10.1007/s11605-013-2206-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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Colorectal cancer in a monoallelic MYH mutation carrier.PMID 23625202Read ↗

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Implication of MYH in Colorectal PolyposisSemantic proximity Read ↗

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Identification of MYH mutation carriers in colorectal cancer: a multicenter, case-control, population-based study.Semantic proximity Read ↗

Similar colorectal cancer risk in patients with monoallelic and biallelic mutations in the MYH gene identified in a population with adenomatous polyposis.Semantic proximity Read ↗

Biallelic germline mutations in MYH predispose to multiple colorectal adenoma and somatic G:C-->T:A mutations.Semantic proximity Read ↗

Pathological features of colorectal carcinomas in MYH‐associated polyposisSemantic proximity Read ↗

Microsatellite stable colorectal cancers in clinically suspected hereditary nonpolyposis colorectal cancer patients without vertical transmission of disease are unlikely to be caused by biallelic germline mutations in MYH.Semantic proximity Read ↗

Risk of colorectal cancer for carriers of mutations in MUTYH, with and without a family history of cancer.Semantic proximity Read ↗

Risk of colorectal cancer in monoallelic and biallelic carriers of MYH mutations: a population-based case-family study.Semantic proximity Read ↗

Correlation of polyp number and family history of colon cancer with germline MYH mutations.Semantic proximity Read ↗

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