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Article

PTEN protein phosphatase activity regulates hepatitis C virus secretion through modulation of cholesterol metabolism.

Journal of hepatology - 1 Sept 2013

Peyrou Marion, Clément Sophie, Maier Christiane, Bourgoin Lucie, Branche Emilie, Conzelmann Stéphanie, Kaddai Vincent, Foti Michelangelo, Negro Francesco

Abstract excerpt

BACKGROUND & AIMS: Hepatitis C virus (HCV) infection is dependent on lipid metabolism. Hepatocyte steatosis occurs frequently in HCV infection, but the relationship between steatosis and HCV life cycle is unclear. We showed that HCV induces steatosis via the downregulation of the phosphatase and tensin homolog deleted on chromosome 10 (PTEN). We here investigated how PTEN may affect HCV production. METHODS: The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23623999
DOI: 10.1016/j.jhep.2013.04.012

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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