Article
Uterine Leiomyomas with an Apparently Normal Karyotype Comprise Minor Heteroploid Subpopulations Differently Represented in vivo and in vitro.
Cytogenetic and genome research - 1 Jan 2021
Koltsova Alla S, Efimova Olga A, Pendina Anna A, Chiryaeva Olga G, Osinovskaya Natalia S, Shved Natalia Y, Yarmolinskaya Maria I, Polenov Nikolai I, Kunitsa Vladislava V, Sagurova Yanina M, Tral Tatyana G, Tolibova Gulrukhsor K, Baranov Vladislav S
Abstract excerpt
In the present study, we aimed to check whether uterine leiomyomas (ULs) with an apparently normal karyotype in vitro comprise "hidden" cell subpopulations with numerical chromosome abnormalities (heteroploid cells). A total of 32 ULs obtained from 32 patients were analyzed in the study. Each UL was sampled for in vivo and in vitro cytogenetic studies. Karyotyping was performed on metaphase preparations from the...
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