Myeloperoxidase Modulates Inflammation in Generalized Pustular Psoriasis and Additional Rare Pustular Skin Diseases.

doi:10.1016/j.ajhg.2020.07.001

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Article

Myeloperoxidase Modulates Inflammation in Generalized Pustular Psoriasis and Additional Rare Pustular Skin Diseases.

American journal of human genetics - 3 Sept 2020

Haskamp Stefan, Bruns Heiko, Hahn Madelaine, Hoffmann Markus, Gregor Anne, Löhr Sabine, Hahn Jonas, Schauer Christine, Ringer Mark, Flamann Cindy, Frey Benjamin, Lesner Adam, Thiel Christian T, Ekici Arif B, von Hörsten Stephan, Aßmann Gunter, Riepe Claudia, Euler Maximilien, Schäkel Knut, Philipp Sandra, Prinz Jörg C, Mößner Rotraut, Kersting Florina, Sticherling Michael, Sefiani Abdelaziz, Lyahyai Jaber, Sondermann Wiebke, Oji Vinzenz, Schulz Peter, Wilsmann-Theis Dagmar, Sticht Heinrich, Schett Georg, Reis André, Uebe Steffen, Frey Silke, Hüffmeier Ulrike

Abstract excerpt

Generalized pustular psoriasis (GPP) is a severe multi-systemic inflammatory disease characterized by neutrophilic pustulosis and triggered by pro-inflammatory IL-36 cytokines in skin. While 19%-41% of affected individuals harbor bi-allelic mutations in IL36RN, the genetic cause is not known in most cases. To identify and characterize new pathways involved in the pathogenesis of GPP, we performed whole-exome...

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Identifiers

PMID: 32758447
DOI: 10.1016/j.ajhg.2020.07.001
PMCID: PMC7477008

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