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Integrating genomics in head and neck cancer treatment: Promises and pitfalls.

Critical reviews in oncology/hematology - 1 Sept 2015

Thariat Juliette, Vignot Stéphane, Lapierre Ariane, Falk Alexander T, Guigay Joel, Van Obberghen-Schilling Ellen, Milano Gerard

Abstract excerpt

Head and neck squamous cell carcinomas (HNSCC) represent a multifactorial disease of poor prognosis. They have lagged behind other cancers in terms of personalized therapy. With expansion and high throughput sequencing methods, recent landmark exonic studies and Cancer Genome Atlas data have identified genes relevant to carcinogenesis and cancer progression. Mutational profiles and rates vary widely depending on...

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PMID: 25979769
DOI: 10.1016/j.critrevonc.2015.03.005

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