Article
Putting pleiotropy and selection into context defines a new paradigm for interpreting genetic data.
Circulation. Cardiovascular genetics - 1 Jun 2013
Predazzi Irene M, Rokas Antonis, Deinard Amos, Schnetz-Boutaud Nathalie, Williams Nicholas D, Bush William S, Tacconelli Alessandra, Friedrich Klaus, Fazio Sergio, Novelli Giuseppe, Haines Jonathan L, Sirugo Giorgio, Williams Scott M
Abstract excerpt
BACKGROUND: Natural selection shapes many human genes, including some related to complex diseases. Understanding how selection affects genes, especially pleiotropic ones, may be important in evaluating disease associations and the role played by environmental variation. This may be of particular interest for genes with antagonistic roles that cause divergent patterns of selection. The lectin-like low-density...
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