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Article

Lysine 313 of T-box is crucial for modulation of protein stability, DNA binding, and threonine phosphorylation of T-bet.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 2013

Jang Eun Jung, Park Hye Ryeon, Hong Jeong-Ho, Hwang Eun Sook

Abstract excerpt

A T-box-containing protein expressed in T cells (T-bet) is a key transcription factor involved in the regulation of Th cell differentiation. Although T-bet-deficient CD4(+) T cells fail to produce IFN-γ and typically differentiate into Th2 cells in vitro, ectopic overexpression of T-bet elevates IFN-γ and suppresses production of IL-2 and Th2 cytokines through different mechanisms. Despite the importance of the...

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Identifiers

PMID: 23616576
DOI: 10.4049/jimmunol.1203403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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