Article
Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change.
Proceedings of the National Academy of Sciences of the United States of America - 7 Feb 2006
Gallagher Ewen, Gao Min, Liu Yun-Cai, Karin Michael
Abstract excerpt
The E3 ubiquitin (Ub) ligase Itch is a critical regulator of T helper 2 (Th2) cytokine production through its ability to induce Ub-dependent JunB degradation. After T cell receptor engagement, Itch undergoes JNK1-mediated phosphorylation that greatly enhances its enzymatic activity. To investigate how phosphorylation activates an E3 Ub ligase we have identified the JNK1 phosphorylation sites within Itch as S199,...
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