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Article

The mitochondrial Hsp70 chaperone Ssq1 facilitates Fe/S cluster transfer from Isu1 to Grx5 by complex formation.

Molecular biology of the cell - 1 Jun 2013

Uzarska Marta A, Dutkiewicz Rafal, Freibert Sven-Andreas, Lill Roland, Mühlenhoff Ulrich

Abstract excerpt

The mitochondrial Hsp70 chaperone Ssq1 plays a dedicated role in the maturation of iron-sulfur (Fe/S) proteins, an essential process of mitochondria. Similar to its bacterial orthologue HscA, Ssq1 binds to the scaffold protein Isu1, thereby facilitating dissociation of the newly synthesized Fe/S cluster on Isu1 and its transfer to target apoproteins. Here we use in vivo and in vitro approaches to show that Ssq1...

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PMID: 23615440
DOI: 10.1091/mbc.E12-09-0644
PMCID: PMC3681689

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