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Article

Compensation for a defective interaction of the hsp70 ssq1 with the mitochondrial Fe-S cluster scaffold isu.

The Journal of biological chemistry - 12 Aug 2005

Knieszner Helena, Schilke Brenda, Dutkiewicz Rafal, D'Silva Patrick, Cheng Sara, Ohlson Maikke, Craig Elizabeth A, Marszalek Jaroslaw

Abstract excerpt

Ssq1, a specialized yeast mitochondrial Hsp70, plays a critical role in the biogenesis of proteins containing Fe-S clusters through its interaction with Isu, the scaffold on which clusters are built. Two substitutions within the Ssq1 substrate binding cleft, both of which severely reduced affinity for Isu, had very different effects in vivo. Cells expressing Ssq1(F462S), which had no detectable affinity for Isu,...

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PMID: 15958384
DOI: 10.1074/jbc.M503031200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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Compensation for a defective interaction of the hsp70 ssq1 with the mitochondrial Fe-S cluster scaffold isu.PMID 15958384Read ↗

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