Article
Microphthalmia transcription factor regulates pancreatic β-cell function.
Diabetes - 1 Aug 2013
Mazur Magdalena A, Winkler Marcus, Ganic Elvira, Colberg Jesper K, Johansson Jenny K, Bennet Hedvig, Fex Malin, Nuber Ulrike A, Artner Isabella
Abstract excerpt
Precise regulation of β-cell function is crucial for maintaining blood glucose homeostasis. Pax6 is an essential regulator of β-cell-specific factors like insulin and Glut2. Studies in the developing eye suggest that Pax6 interacts with Mitf to regulate pigment cell differentiation. Here, we show that Mitf, like Pax6, is expressed in all pancreatic endocrine cells during mouse postnatal development and in the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.