Article
Mechanism of action-based classification of antibiotics using high-content bacterial image analysis.
Molecular bioSystems - 1 Jul 2013
Peach Kelly C, Bray Walter M, Winslow Dustin, Linington Peter F, Linington Roger G
Abstract excerpt
Image-based screening has become a mature field over the past decade, largely due to the detailed information that can be obtained about compound mode of action by considering the phenotypic effects of test compounds on cellular morphology. However, very few examples exist of extensions of this approach to bacterial targets. We now report the first high-throughput, high-content platform for the prediction of...
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