Article
Going forward with genetics: recent technological advances and forward genetics in mice.
The American journal of pathology - 1 May 2013
Moresco Eva Marie Y, Li Xiaohong, Beutler Bruce
Abstract excerpt
Forward genetic analysis is an unbiased approach for identifying genes essential to defined biological phenomena. When applied to mice, it is one of the most powerful methods to facilitate understanding of the genetic basis of human biology and disease. The speed at which disease-causing mutations can be identified in mutagenized mice has been markedly increased by recent advances in DNA sequencing technology....
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