Article
A regulatory variant in the C1Q gene cluster is associated with tuberculosis susceptibility and C1qA plasma levels in a South African population.
Immunogenetics - 1 Jul 2020
Bruiners Natalie, Schurz Haiko, Daya Michelle, Salie Muneeb, van Helden Paul D, Kinnear Craig J, Hoal Eileen G, Möller Marlo, Gey van Pittius Nicolaas C
Abstract excerpt
Several genetic studies have implicated genes that encode for components of the innate immune response in tuberculosis (TB) susceptibility. The complement system is an early player in the innate immune response and provides the host with initial protection by promoting phagocytosis of apoptotic or necrotic cells. The C1q molecule is the first component of the classical pathway that leads to the activation of...
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