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Article

Genetic analysis of cardiac SCN5A Gene in Iranian patients with hereditary cardiac arrhythmias.

Anatolian journal of cardiology - 1 Mar 2016

Asadi Marzi, Foo Roger, Bhuiyan Zahurul Alam, Samienasab Mohammad Reza, Salehi Ahmad Reza, Shahrzad Shahab, Salehi Rasoul

Abstract excerpt

OBJECTIVE: SCN5A encodes alpha subunit of the major sodium channel (Nav1.5) in human cardiac tissue. Malfunction of this cardiac sodium channel is associated with a variety of cardiac arrhythmias and myocardial inherited diseases. METHODS: Fifty-three members from three families each diagnosed with long-QT syndrome type 3 (LQTS3), Brugada syndrome (BrS), or sick sinus syndrome (SSS) were included in this...

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Identifiers

PMID: 26467377
DOI: 10.5152/akd.2015.6060
PMCID: PMC5336802

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