Article
KRAS mutant allele-specific imbalance is associated with worse prognosis in pancreatic cancer and progression to undifferentiated carcinoma of the pancreas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Oct 2013
Krasinskas Alyssa M, Moser A James, Saka Burcu, Adsay N Volkan, Chiosea Simion I
Abstract excerpt
KRAS codon 12 mutations are present in about 90% of ductal adenocarcinomas and in undifferentiated carcinomas of the pancreas. The role of KRAS copy number changes and resulting KRAS mutant allele-specific imbalance (MASI) in ductal adenocarcinoma (n=94), and its progression into undifferentiated carcinoma of the pancreas (n=25) was studied by direct sequencing and KRAS fluorescence in situ hybridization (FISH)....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.