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Article

Features of protein–protein interactions that translate into potent inhibitors: topology, surface area and affinity

1 Jul 2012

Abstract excerpt

Protein-protein interactions (PPIs) control the assembly of multi-protein complexes and, thus, these contacts have enormous potential as drug targets. However, the field has produced a mix of both exciting success stories and frustrating challenges. Here, we review known examples and explore how the physical features of a PPI, such as its affinity, hotspots, off-rates, buried surface area and topology, might...

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PMID: 22831787
DOI: 10.1017/erm.2012.10

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