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Article

Bioinformatics and variability in drug response: a protein structural perspective.

Journal of the Royal Society, Interface - 7 Jul 2012

Lahti Jennifer L, Tang Grace W, Capriotti Emidio, Liu Tianyun, Altman Russ B

Abstract excerpt

Marketed drugs frequently perform worse in clinical practice than in the clinical trials on which their approval is based. Many therapeutic compounds are ineffective for a large subpopulation of patients to whom they are prescribed; worse, a significant fraction of patients experience adverse eff...

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Identifiers

PMID: 22552919
DOI: 10.1098/rsif.2011.0843
PMCID: PMC3367825

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22552919-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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