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Article

The C-type lectin of the aggrecan G3 domain activates complement.

PloS one - 1 Jan 2013

Melin Fürst Camilla, Mörgelin Matthias, Vadstrup Kasper, Heinegård Dick, Aspberg Anders, Blom Anna M

Abstract excerpt

Excessive complement activation contributes to joint diseases such as rheumatoid arthritis and osteoarthritis during which cartilage proteins are fragmented and released into the synovial fluid. Some of these proteins and fragments activate complement, which may sustain inflammation. The G3 domain of large cartilage proteoglycan aggrecan interacts with other extracellular matrix proteins, fibulins and tenascins,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23596522
DOI: 10.1371/journal.pone.0061407
PMCID: PMC3626604

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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