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Article

The folded modules of aggrecan G3 domain exert two separable functions in glycosaminoglycan modification and product secretion.

The Journal of biological chemistry - 25 Jan 2002

Chen Liwen, Wu Yaojiong, Lee Vivian, Kiani Chris, Adams Mark E, Yao Yeqi, Yang Burton B

Abstract excerpt

Aggrecan is the major proteoglycan in the extracellular matrix of cartilage. A notable exception is nanomelic cartilage, which lacks aggrecan in its matrix. The example of nanomelia and other evidence leads us to believe that the G3 domain plays an important role in aggrecan processing, and it has indeed been confirmed that G3 allows glycosaminoglycan (GAG) chain attachment and product secretion. However, it is...

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Source

Identifiers

PMID: 11714693
DOI: 10.1074/jbc.M101153200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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