Article
Function of the C. elegans T-box factor TBX-2 depends on SUMOylation.
Cellular and molecular life sciences : CMLS - 1 Nov 2013
Huber Paul, Crum Tanya, Clary Lynn M, Ronan Tom, Packard Adelaide V, Okkema Peter G
Abstract excerpt
T-box transcription factors are critical developmental regulators in all multi-cellular organisms, and altered T-box factor activity is associated with a variety of human congenital diseases and cancers. Despite the biological significance of T-box factors, their mechanism of action is not well understood. Here we examine whether SUMOylation affects the function of the C. elegans Tbx2 sub-family T-box factor...
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