Article
Pathway-based genome-wide association analysis identified the importance of EphrinA-EphR pathway for femoral neck bone geometry.
Bone - 1 Jan 2010
Chen Yuan, Xiong Dong-Hai, Guo Yan-Fang, Pan Feng, Zhou Qi, Zhang Feng, Deng Hong-Wen
Abstract excerpt
Femoral neck (FN) bone geometry is an important predictor of bone strength with high heritability. Previous studies have revealed certain candidate genes for FN bone geometry. However, the majority of the underlying genetic factors remain to be discovered. In this study, pathway-based genome-wide association analysis was performed to explore the joint effects of genes within biological pathways on FN bone...
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