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Article

Association of L-ficolin levels and FCN2 genotypes with chronic Chagas disease.

PloS one - 1 Jan 2013

Luz Paola R, Boldt Angelica B W, Grisbach Caroline, Kun Jürgen F J, Velavan Thirumalaisamy P, Messias-Reason Iara J T

Abstract excerpt

BACKGROUND: L-ficolin (encoded by FCN2) binds to acetylated sugar moieties of many pathogens, including Trypanosoma cruzi, promoting their phagocytosis and lysis by the complement system. METHODS: We investigated L-ficolin levels in 160 T. cruzi infected patients with chronic Chagas disease and 71 healthy individuals, and FCN2 polymorphisms (-986 G>A, -602 G>A, and -4 A>G in the promoter and A258S in exon 8) in...

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Source

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Identifiers

PMID: 23593180
DOI: 10.1371/journal.pone.0060237
PMCID: PMC3617223

Genes

FCN2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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