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Article

Developing and applying a gene functional association network for anti-angiogenic kinase inhibitor activity assessment in an angiogenesis co-culture model.

BMC genomics - 2 Jun 2008

Chen Yuefeng, Wei Tao, Yan Lei, Lawrence Frank, Qian Hui-Rong, Burkholder Timothy P, Starling James J, Yingling Jonathan M, Shou Jianyong

Abstract excerpt

BACKGROUND: Tumor angiogenesis is a highly regulated process involving intercellular communication as well as the interactions of multiple downstream signal transduction pathways. Disrupting one or even a few angiogenesis pathways is often insufficient to achieve sustained therapeutic benefits due to the complexity of angiogenesis. Targeting multiple angiogenic pathways has been increasingly recognized as a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18518970
DOI: 10.1186/1471-2164-9-264
PMCID: PMC2435557

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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