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Genistein downregulates onco-miR-1260b and inhibits Wnt-signalling in renal cancer cells

16 Apr 2013

Abstract excerpt

BACKGROUND: Wnt-signalling has an important role in renal cancer and it is modulated by genistein in other cancers. Recently, microRNAs (miRNAs) have emerged as new regulators of gene expression. Thus, we focused on miRNAs to examine the regulatory mechanism of genistein on the Wnt-signalling pathway in renal cell carcinoma (RCC). METHODS: Initially, we investigated the effect of genistein on Wnt-signalling...

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PMID: 23591200
DOI: 10.1038/bjc.2013.173

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