Article
The beta 1a subunit is essential for the assembly of dihydropyridine-receptor arrays in skeletal muscle.
Proceedings of the National Academy of Sciences of the United States of America - 22 Nov 2005
Schredelseker Johann, Di Biase Valentina, Obermair Gerald J, Felder E Tatiana, Flucher Bernhard E, Franzini-Armstrong Clara, Grabner Manfred
Abstract excerpt
Homozygous zebrafish of the mutant relaxed (red(ts25)) are paralyzed and die within days after hatching. A significant reduction of intramembrane charge movements and the lack of depolarization-induced but not caffeine-induced Ca(2+) transients suggested a defect in the skeletal muscle dihydropyridine receptor (DHPR). Sequencing of DHPR cDNAs indicated that the alpha(1S) subunit is normal, whereas the beta(1a)...
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