Article
gp100(209-2M) peptide immunization of human lymphocyte antigen-A2+ stage I-III melanoma patients induces significant increase in antigen-specific effector and long-term memory CD8+ T cells.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2004
Walker Edwin B, Haley Daniel, Miller William, Floyd Kevin, Wisner Ketura P, Sanjuan Nelson, Maecker Holden, Romero Pedro, Hu Hong-Ming, Alvord W Gregory, Smith John W, Fox Bernard A, Urba Walter J
Abstract excerpt
Thirty-five HLA-A2(+) patients with completely resected stage I-III melanoma were vaccinated multiple times over 6 months with a modified melanoma peptide, gp100(209-2M), emulsified in Montanide adjuvant. Direct ex vivo gp100(209-2M) tetramer analysis of pre- and postvaccine peripheral blood mononuclear cells (PBMCs) demonstrated significant increases in the frequency of tetramer(+) CD8(+) T cells after...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.