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Article

MEK1/2 inhibition enhances the radiosensitivity of cancer cells by downregulating survival and growth signals mediated by EGFR ligands.

International journal of oncology - 1 Jun 2013

Chung Eun Joo, Urick Mary Ellen, Kurshan Naamit, Shield William, Asano Hiroaki, Smith Paul D, Scroggins Bradley S, Burkeen Jeffrey, Citrin Deborah E

Abstract excerpt

The inhibition of the Ras/mitogen-activated protein kinase (Ras/MAPK) pathway through the suppression of mutated Ras or MAPK/extracellular signal-regulated kinase 1/2 (MEK1/2) has been shown to sensitize tumor cells to ionizing radiation (IR). The molecular mechanisms of this sensitization howeve...

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Source

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Identifiers

PMID: 23588995
DOI: 10.3892/ijo.2013.1890
PMCID: PMC3699614

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23588995-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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