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Article

MEK1/2 inhibition enhances the radiosensitivity of cancer cells by downregulating survival and growth signals mediated by EGFR ligands.

International journal of oncology - 1 Jun 2013

Chung Eun Joo, Urick Mary Ellen, Kurshan Naamit, Shield William, Asano Hiroaki, Smith Paul D, Scroggins Bradley S, Burkeen Jeffrey, Citrin Deborah E

Abstract excerpt

The inhibition of the Ras/mitogen-activated protein kinase (Ras/MAPK) pathway through the suppression of mutated Ras or MAPK/extracellular signal-regulated kinase 1/2 (MEK1/2) has been shown to sensitize tumor cells to ionizing radiation (IR). The molecular mechanisms of this sensitization however, are not yet fully understood. In this study, we investigated the role of transforming growth factor-α (TGF-α) in the...

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Identifiers

PMID: 23588995
DOI: 10.3892/ijo.2013.1890
PMCID: PMC3699614

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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