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Precursor-B-ALL with D(H)-J(H) gene rearrangements have an immature immunogenotype with a high frequency of oligoclonality and hyperdiploidy of chromosome 14.

Leukemia - 1 Sept 2001

Szczepański T, Willemse M J, van Wering E R, van Weerden J F, Kamps W A, van Dongen J J

Abstract excerpt

The IGH gene configuration was investigated in 97 childhood precursor-B-ALL patients at initial diagnosis. Rearrangements were found by Southern blotting in all but three patients (97%) and in 30 cases (31%) we observed oligoclonal IGH gene rearrangements. Heteroduplex PCR analysis revealed at least one clonal PCR product in all Southern blot-positive cases. In 89 patients (92%) complete V(D)J rearrangements were...

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Share to Chromosomes, Human, Pair 14
Share to Gene Rearrangement, B-Lymphocyte, Heavy Chain

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Immunoglobulin

Share to Heteroduplex Analysis

Share to Immunogenetics

Share to Immunoglobulin Joining Region

Share to Leukemia, B-Cell

Share to Neoplasm, Residual

Source

Identifiers

PMID: 11516102
DOI: 10.1038/sj.leu.2402206

Genes

IGH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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