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Predicting substrates of the human breast cancer resistance protein using a support vector machine method

15 Apr 2013

Abstract excerpt

BACKGROUND: Human breast cancer resistance protein (BCRP) is an ATP-binding cassette (ABC) efflux transporter that confers multidrug resistance in cancers and also plays an important role in the absorption, distribution and elimination of drugs. Prediction as to if drugs or new molecular entities are BCRP substrates should afford a cost-effective means that can help evaluate the pharmacokinetic properties,...

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PMID: 23586520
DOI: 10.1186/1471-2105-14-130

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