Opposing chemokine gradients control human thymocyte migration in situ

Abstract excerpt

The ordered migration of thymocytes from the cortex to the medulla is critical for the appropriate selection of the mature T cell repertoire. Most studies of thymocyte migration rely on mouse models, but we know relatively little about how human thymocytes find their appropriate anatomical niches within the thymus. Moreover, the signals that retain CD4+CD8+ double-positive (DP) thymocytes in the cortex and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Chemokine receptors and signaling
• Share to Immunotherapy and Immune Responses
• Share to T-cell and B-cell Immunology