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Article

The murine chemokine receptor CXCR4 is tightly regulated during T cell development and activation

1 Dec 1999

Abstract excerpt

We have characterized the murine homolog of the HIV-co-receptor CXCR4 during T cell development and activation. Our data demonstrate that this chemokine receptor, although highly conserved between human and mouse, is differently expressed and regulated in both species. Mitogenic activation resulted in an increase of surface CXCR4 on murine T cells within 2 days, whereas the receptor was strongly down-regulated on...

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PMID: 10614783
DOI: 10.1002/jlb.66.6.996

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