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Article

A complex deoxyribonucleic acid looping configuration associated with the silencing of the maternal Igf2 allele.

Molecular endocrinology (Baltimore, Md.) - 1 Jun 2008

Qiu Xinwen, Vu Thanh H, Lu Qiucheng, Ling Jian Qun, Li Tao, Hou Aiju, Wang Shu Kui, Chen Hui Ling, Hu Ji Fan, Hoffman Andrew R

Abstract excerpt

Alternate interactions between the H19 imprinting control region (ICR) and one of the two Igf2 differentially methylated regions has been proposed as a model regulating the reciprocal imprinting of Igf2 and H19. To study the conformation of this imprint switch, we performed a systematic structural analysis across the 140 kb of the mouse Igf2-H19 region, which includes enhancers located both between the two genes...

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Identifiers

PMID: 18356289
DOI: 10.1210/me.2007-0474
PMCID: PMC2422825

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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A complex deoxyribonucleic acid looping configuration associated with the silencing of the maternal Igf2 allele.PMID 18356289Read ↗

CTCF binding at the <i>H19</i> imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to <i>Igf2</i>Semantic proximity Read ↗

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Imprinting and looping: epigenetic marks control interactions between regulatory elements.Semantic proximity Read ↗

Induced DNA demethylation can reshape chromatin topology at the IGF2-H19 locusSemantic proximity Read ↗

CTCF is the master organizer of domain-wide allele-specific chromatin at the H19/Igf2 imprinted region.Semantic proximity Read ↗

The 5' flank of mouse H19 in an unusual chromatin conformation unidirectionally blocks enhancer-promoter communication.Semantic proximity Read ↗

The human and mouse H19 imprinting control regions harbor an evolutionarily conserved silencer element that functions on transgenes in Drosophila.Semantic proximity Read ↗

Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loopsSemantic proximity Read ↗

Mechanisms of Igf2/H19 Imprinting: DNA Methylation, Chromatin and Long-Distance Gene RegulationSemantic proximity Read ↗

CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb repressive complex 2 intrachromosomal loop.Semantic proximity Read ↗

Epigenetic regulation of the <i>Igf2/H19</i> gene clusterSemantic proximity Read ↗

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