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Article

Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene

1 May 2000

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Share to Epigenetics and DNA Methylation
Share to Genetic Syndromes and Imprinting
Share to Prenatal Screening and Diagnostics

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 10839546
DOI: 10.1038/35013100

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 genePMID 10839546Read ↗

CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locusSemantic proximity Read ↗

CTCF is the master organizer of domain-wide allele-specific chromatin at the H19/Igf2 imprinted region.Semantic proximity Read ↗

CTCF maintains differential methylation at the Igf2/H19 locus.Semantic proximity Read ↗

CTCF binding at the <i>H19</i> imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to <i>Igf2</i>Semantic proximity Read ↗

Genomic Imprinting: CTCF Protects the BoundariesSemantic proximity Read ↗

CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb repressive complex 2 intrachromosomal loop.Semantic proximity Read ↗

Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signalSemantic proximity Read ↗

More than insulator: multiple roles of CTCF at the H19-Igf2 imprinted domainSemantic proximity Read ↗

CTCF binding sites promote transcription initiation and prevent DNA methylation on the maternal allele at the imprinted H19/Igf2 locus.Semantic proximity Read ↗

Imprinted expression of the Igf2r gene depends on an intronic CpG islandSemantic proximity Read ↗

Genomic imprinting controls matrix attachment regions in the Igf2 gene.Semantic proximity Read ↗

Induced DNA demethylation can reshape chromatin topology at the IGF2-H19 locusSemantic proximity Read ↗

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