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Article

Development of Akt-activated GSK3β inhibitory peptide.

Biochemical and biophysical research communications - 17 May 2013

Kim Jin-Sik, Piao Shunfu, Lee Eunjin, Yoon Bo-Young, Moon Hyung Ryong, Lee Jaewon, Jung Yunjin, Ha Nam-Chul

Abstract excerpt

Abnormal overexpression of GSK3β has been implicated in insulin resistance. Although many potent GSK3β inhibitors have been developed as drug candidates for anti-insulin resistance, the inhibitors are prone to show side effects because they interfere with normal GSK3β function without regulation. Recently, it was reported that the PPPSPxS motifs in the Wnt coreceptor LRP6 were able to directly inhibit GSK3β only...

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Identifiers

PMID: 23583197
DOI: 10.1016/j.bbrc.2013.03.103

Genes

LRP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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