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Article

Unraveling the role of Arg4 and Arg6 in the auto-inhibition mechanism of GSK3β from molecular dynamics simulation.

Chemical biology & drug design - 1 Jun 2014

Mou Linkai, Li Molin, Lu Shao-Yong, Li Shuai, Shen Qiancheng, Zhang Jian, Li Chuangang, Lu Xuefeng

Abstract excerpt

Glycogen synthase kinase 3β (GSK3β) is a multifunctional serine/threonine protein kinase that is involved in several biological processes including insulin and Wnt signaling pathways. GSK3β can be phosphorylated by the protein kinase B (PKB). The mutations of Arg4 and Arg6 to alanine at N-terminal GSK3β have been reported to impair its ability to autophosphorylate at Ser9. Despite the extensive experimental...

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PMID: 24444018
DOI: 10.1111/cbdd.12286

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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