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Article

β2 adrenergic receptor, protein kinase A (PKA) and c-Jun N-terminal kinase (JNK) signaling pathways mediate tau pathology in Alzheimer disease models.

The Journal of biological chemistry - 12 Apr 2013

Wang Dayong, Fu Qin, Zhou Yuan, Xu Bing, Shi Qian, Igwe Benedict, Matt Lucas, Hell Johannes W, Wisely Elena V, Oddo Salvatore, Xiang Yang K

Abstract excerpt

Alzheimer disease (AD) is characterized by neurodegeneration marked by loss of synapses and spines associated with hyperphosphorylation of tau protein. Accumulating amyloid β peptide (Aβ) in brain is linked to neurofibrillary tangles composed of hyperphosphorylated tau in AD. Here, we identify β2-adrenergic receptor (β2AR) that mediates Aβ-induced tau pathology. In the prefrontal cortex (PFC) of 1-year-old...

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Identifiers

PMID: 23430246
DOI: 10.1074/jbc.M112.415141
PMCID: PMC3624413

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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