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Article

Overlapping roles and asymmetrical cross-regulation of the USF proteins in mice.

Proceedings of the National Academy of Sciences of the United States of America - 31 Mar 1998

Sirito M, Lin Q, Deng J M, Behringer R R, Sawadogo M

Abstract excerpt

USF1 and USF2 are ubiquitously expressed transcription factors implicated as antagonists of the c-Myc protooncoprotein in the control of cellular proliferation. To determine the biological role of the USF proteins, mutant mice were generated by homologous recombination in embryonic stem cells. USF1-null mice were viable and fertile, with only slight behavioral abnormalities. However, these mice contained elevated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 9520440
DOI: 10.1073/pnas.95.7.3758
PMCID: PMC19910

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