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Article

SEC23B is required for the maintenance of murine professional secretory tissues.

Proceedings of the National Academy of Sciences of the United States of America - 17 Jul 2012

Tao Jiayi, Zhu Min, Wang He, Afelik Solomon, Vasievich Matthew P, Chen Xiao-Wei, Zhu Guojing, Jensen Jan, Ginsburg David, Zhang Bin

Abstract excerpt

In eukaryotic cells, newly synthesized secretory proteins require COPII (coat protein complex II) to exit the endoplasmic reticulum (ER). COPII contains five core components: SAR1, SEC23, SEC24, SEC13, and SEC31. SEC23 is a GTPase-activating protein that activates the SAR1 GTPase and also plays a...

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Share to Anthraquinones
Share to Endoplasmic Reticulum
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22745161
DOI: 10.1073/pnas.1209207109
PMCID: PMC3406820

Genes

SEC13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22745161-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

SEC23B is required for the maintenance of murine professional secretory tissues.PMID 22745161Read ↗

A common SEC23B missense mutation in congenital dyserythropoietic anemia type II leads to growth restriction and symptoms of chronic pancreatitis in miceSemantic proximity Read ↗

A common human missense mutation of vesicle coat protein SEC23B leads to growth restriction and chronic pancreatitis in mice.Semantic proximity Read ↗

Pancreatic SEC23B deficiency is sufficient to explain the perinatal lethality of germline SEC23B deficiency in mice.Semantic proximity Read ↗

Mutations affecting the secretory COPII coat component SEC23B cause congenital dyserythropoietic anemia type II.Semantic proximity Read ↗

Functions of the COPII gene paralogs SEC23A and SEC23B are interchangeable in vivoSemantic proximity Read ↗

The Function of the COPII Gene Paralogs SEC23A and SEC23B Are Interchangeable <i>In Vivo</i>Semantic proximity Read ↗

Sec13 safeguards the integrity of the endoplasmic reticulum and organogenesis of the digestive system in zebrafish.Semantic proximity Read ↗

Characteristic phenotypes associated with congenital dyserythropoietic anemia (type II) manifest at different stages of erythropoiesis.Semantic proximity Read ↗

Non-canonical role of wild-type SEC23B in the cellular stress response pathway.Semantic proximity Read ↗

Absence of a red blood cell phenotype in mice with hematopoietic deficiency of SEC23B.Semantic proximity Read ↗

SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion.Semantic proximity Read ↗

Hypomorphic mutations of SEC23B gene account for mild phenotypes of congenital dyserythropoietic anemia type II.Semantic proximity Read ↗

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