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Article

A common human missense mutation of vesicle coat protein SEC23B leads to growth restriction and chronic pancreatitis in mice.

The Journal of biological chemistry - 1 Jan 2022

Wei Wei, Liu Zhigang, Zhang Chao, Khoriaty Rami, Zhu Min, Zhang Bin

Abstract excerpt

SEC23B is one of two vertebrate paralogs of SEC23, a key component of the coat protein complex II vesicles. Complete deficiency of SEC23B in mice leads to perinatal death caused by massive degeneration of professional secretory tissues. However, functions of SEC23B in postnatal mice and outside professional secretory tissues are unclear. In this study, we generated a Sec23b KO mouse and a knockin (KI) mouse with...

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Share to Anemia, Dyserythropoietic, Congenital
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation, Missense

Share to Pancreatitis, Chronic

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Source

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Identifiers

PMID: 34954140
DOI: 10.1016/j.jbc.2021.101536
PMCID: PMC8760524

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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