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Article

Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis.

PLoS genetics - 1 Apr 2006

Scacheri Peter C, Davis Sean, Odom Duncan T, Crawford Gregory E, Perkins Stacie, Halawi Mohamad J, Agarwal Sunita K, Marx Stephen J, Spiegel Allen M, Meltzer Paul S, Collins Francis S

Abstract excerpt

Multiple endocrine neoplasia type I (MEN1) is a familial cancer syndrome characterized primarily by tumors of multiple endocrine glands. The gene for MEN1 encodes a ubiquitously expressed tumor suppressor protein called menin. Menin was recently shown to interact with several components of a trithorax family histone methyltransferase complex including ASH2, Rbbp5, WDR5, and the leukemia proto-oncoprotein MLL. To...

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Identifiers

PMID: 16604156
DOI: 10.1371/journal.pgen.0020051
PMCID: PMC1428788

Genes

MEN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis.PMID 16604156Read ↗

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Genome-Wide Characterization of Menin-Dependent H3K4me3 Reveals a Specific Role for Menin in the Regulation of Genes Implicated in MEN1-Like TumorsSemantic proximity Read ↗

Menin, Histone H3 Methyltransferases, and Regulation of Cell Proliferation: Current Knowledge and PerspectiveSemantic proximity Read ↗

Menin Molecular Interactions: Insights into Normal Functions and TumorigenesisSemantic proximity Read ↗

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