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Article

IL-6 restores dendritic cell maturation inhibited by tumor-derived TGF-β through interfering Smad 2/3 nuclear translocation.

Cytokine - 1 Jun 2013

Lin Chen-Si, Chen Mo-Fan, Wang Yu-Shan, Chuang Tien-Fu, Chiang Yi-Lun, Chu Rea-Min

Abstract excerpt

We previously found, in a canine transferable tumor model, that high concentration of IL-6 produced by tumor-infiltrating lymphocytes effectively restores the MHC expression of the tumor cells and T-cell activation inhibited by tumor-derived TGF-β. This tumor also significantly suppresses monocyt...

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Identifiers

PMID: 23579028
DOI: 10.1016/j.cyto.2013.03.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23579028-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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